Digoxin comes from Digitalis lanata. I. 1992;97(1):1-7. 1991;41(4):378-384.
BMJ 4-6-1996;312(7035):912. Aust.Fam.Physician 1993;22(6):997-999. View abstract.Hsu, C. L. and Yen, G. C. Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats. Foxglove is poisonous to humans but attracts bees and hummingbirds. Pharm.Bull. View abstract.OKANO, A., HOJI, K., MIKI, T., and MIYATAKE, K. Studies on the constituents of Digitalis purpurea L. IV.
View abstract.Riehle, M., Bereiter-Hahn, J., and Boller, B. 2005;16(6):393-398. 1957;5(3):272-276. B., Martin, M. A., Izquierdo-Pulido, M., Goya, L., Bravo, L., and Ramos, S. Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line. Antiviral Res. 1986;11(1):3-9.
Neuroreport 5-23-2003;14(7):1067-1070. 1991;11(1-4):687-698. 1984;27(1):21-56. View abstract.Zhang, Y. H., Park, Y. S., Kim, T. J., Fang, L. H., Ahn, H. Y., Hong, J. T., Kim, Y., Lee, C. K., and Yun, Y. P. Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin.
J.Clin.Hosp.Pharm. 2007;64(2):133-144. J Thromb Haemost 2005;3(2):369-376. Hosp.Med 2002;63(12):758-759.
Pharm.Bull. 2007;30(3):605-613. View abstract.Granado-Serrano, A.
2004;18(5):408-413. Pharm.Bull.
1958;10(4):237-241. View abstract.Slifman, N. R., Obermeyer, W. R., Aloi, B. K., Musser, S. M., Correll, W. A., Jr., Cichowicz, S. M., Betz, J. M., and Love, L. A. J Pharm Pharmacol 2007;59(11):1543-1548.
5-30-1981;101(15):949-950. The role of chromium in alkaloid metabolism]. 2008;26(3):320-328. View abstract.Xu, L. N., Xu, D. C., Zhang, B. J., and Wang, R. L. [Studies on mechanism of the antiplatelet effect of sodium ferulate--effect on TXA2/PGI2 balance]. Enzymatic decomposition of glucodigifucoside. In the course of recording and eventually publishing his findings he found that foxglove extract was an effective method for treating dropsy and heart failure – though he also discovered it could have unpleasant effects if given in too high a dose. J Pharm.Pharmacol. Chin J Physiol 6-30-2007;50(3):121-126. View abstract.Hauptman, P. J. and Kelly, R. A. Digitalis. 2003;55(2):239-244. View abstract.Rathore, S. S., Wang, Y., and Krumholz, H. M. Sex-based differences in the effect of digoxin for the treatment of heart failure. After Withering’s work, it became a common treatment for heart issues, including heart failure. Biochem.Pharmacol. View abstract.Kim, S. H., Jun, C. D., Suk, K., Choi, B. J., Lim, H., Park, S., Lee, S. H., Shin, H. Y., Kim, D. K., and Shin, T. Y. Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. View abstract.Srinivasan, M., Rukkumani, R., Ram, Sudheer A., and Menon, V. P. Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity. Boerl, on human cancer cell lines. Carcinogenesis 2007;28(8):1780-1787. Some antibiotics might increase how much foxglove the body absorbs.
View abstract.Lovkova, M. I., Buzuk, G. N., Sokolova, S. M., Kliment'eva, N. I., Ponomareva, S. M., Shelepova, O. V., and Vorotnitskaia, I. E. [Medicinal plants--concentrators of chromium. Rinsho Shinkeigaku 1988;28(3):338-341. View abstract.Srinivasan, M., Sudheer, A. R., and Menon, V. P. Ferulic Acid: therapeutic potential through its antioxidant property. View abstract.Brustbauer, R. and Wenisch, C. [Bradycardiac atrial fibrillation after consuming herbal tea]. Digitalis intoxication? Eds. View abstract.HARKISS, K. J. and RIGBY, G. J. Antivir.Chem.Chemother. Arch.Pharm.Res. View abstract.Burnham TH, ed. Br.J Clin.Pharmacol. Pharmacol.Biochem.Behav. J Chromatogr. Eur.J Emerg.Med 2007;14(6):356-359. 1957;5(2):171-176. ).There is a suggestion that the yellow vision (“xanthopsia”) induced by high levels of digitalis were responsible for the unusually yellow cast to the paintings of Vincent Van Gogh.
J Pharm.Pharmacol. Pharm.Bull. Part II. Mol.Cancer Ther 2006;5(12):3294-3302. Contraception 1981;23(6):677-686. View abstract.Chung TW, Moon SK, Chang YC, et al. Circulation 3-9-1999;99(9):1265-1270. You need to ingest very little to experience toxic effects; if you notice symptoms, or think you or someone you know might have accidentally ingested some part of a foxglove, seek medical attention immediately. View abstract.Uozaki, M., Yamasaki, H., Katsuyama, Y., Higuchi, M., Higuti, T., and Koyama, A. H. Antiviral effect of octyl gallate against DNA and RNA viruses. To answer this, we need more insight into how it affects the body. 1955;7(11):942-953. 7-25-1997;122(30):930-932. J Clin.Biochem.Nutr 2007;40(2):92-100. View abstract.Howdieshell, T. R., Gay, M., DiPiro, J. T., Mooney, S., Duvall, R., Eckles, S., and Baisden, R. Heparin versus citrate regional anticoagulation during autotransfusion in a porcine intra-abdominal hemorrhage model. 3-7-2007;55(5):2020-2027. View abstract.Brewer, L. A., III. View abstract.Mitchell, G. Foxed by the foxglove. View abstract.Johnson JA, Lalonde RL. View abstract.Oh, J. W., Lee, J. Y., Han, S. H., Moon, Y. H., Kim, Y. G., Woo, E. R., and Kang, K. W. Effects of phenylethanoid glycosides from Digitalis purpurea L. on the expression of inducible nitric oxide synthase. 1982;17(3):405-411.
1984;6(6):414-417. Pharmazie 2005;60(6):444-447. Note. J Pharm.Pharmacol. 1-15-2008;226(2):178-191. There is plenty of cultural heritage tied to the foxglove flower.
Back then, it was used as a treatment for ‘dropsy’, what we now recognise as edema, an excess of fluid collecting in the tissues of various parts of the body. The glycosides in foxgloves are found in higher concentrations in the leaves, but they’re still found in all other parts of the plant as well.Ingestion of a small amount of parts of a foxglove can cause symptoms including nausea, vomiting, and diarrhoea.
Life Sci 11-30-2007;81(23-24):1602-1614. Therapeutic and toxic effects of digitalis: William Withering, 1785. 1998;357(1):54-62. Mol.Cancer Ther 2007;6(7):2127-2138. Br.J Nutr 2007;98(4):727-735. Drug Facts and Comparisons, Updated Monthly.
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