Gleason score (GS) 10 disease is the most aggressive form of clinically localized prostate adenocarcinoma (PCa). J Endourology 2000; 14:367-370.D'Amico AV, Tempany CM, Cormack R, Hata N, Jinzaki M, Tuncali K, Weinstein M, Richie JP. Dr Marc B. Garnick led the course from 1982 to 1996 at which time Dr Jerome P. Richie assumed … However, patients with unfavorable intermediate risk (UIR) disease are often recommended trimodality therapy involving BT, androgen deprivation therapy (ADT), and external beam radiation therapy (EBRT...In Reply We thank Dr Baker for his Letter and agree that an optimal way to select men at highest risk for death, as well as for entry onto randomized clinical trials assessing the impact on survival of adding androgen deprivation therapy to novel agents shown to overcome castration resistance, is by combining prostate-specific antigen (PSA) nadir g...Importance: Individual patient data...Background: [email protected]. To explore whether a subgroup of men with unfavorable-risk prostate cancer (PC) exists in whom high-dose radiation therapy (RT) alone is sufficient to avoid excess PC death due to competing risk from cardiometabolic comorbidity. Active surveillance (AS), per the National Comprehensive Cancer Network (NCCN) guidelines, is considered for patients with low-risk prostate cancer (PC) and a life expectancy of at least 10 years.
P...Purpose:We propose an innovative combinatorial treatment strategy of Local ChemoRadiation Therapy (LCRT) using a sustained drug delivery platform in the form of a spacer to locally radio-sensitize the prostate with Docetaxel (DTX) enabling a synergistic cure with the use of lower radiation doses. All rights reserved.Uniformed Services University of the Health Sciences,Association Between Androgen Deprivation Therapy and Patient-reported Depression in Men With Recurrent Prostate Cancer,Clinical Outcomes for Patients With Gleason Score 10 Prostate Adenocarcinoma: Results From a Multi-institutional Consortium Study,Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy Boost and Disease Progression and Mortality in Patients With Gleason Score 9-10 Prostate Cancer,Conventional Versus Hypofractionated Radiation Therapy for Localized Prostate Cancer: A Meta-analysis of Randomized Noninferiority Trials,Brachytherapy monotherapy may be sufficient for a subset of patients with unfavorable intermediate risk prostate cancer,Validity of Surrogate End Points for Prostate Cancer—Reply,Surrogate End Points for All-Cause Mortality in Men With Localized Unfavorable-Risk Prostate Cancer Treated With Radiation Therapy vs Radiation Therapy Plus Androgen Deprivation Therapy: A Secondary Analysis of a Randomized Clinical Trial,ACR Appropriateness Criteria Locally Advanced, High-Risk Prostate Cancer,Androgen Deprivation Therapy Use in the Setting of High-Dose Radiation Therapy and the Risk of Prostate Cancer-Specific Mortality Stratified by the Extent of Competing Mortality,Gleason score and the risk of cause-specific and all-cause mortality following radiation with or without 6 months of androgen deprivation therapy for men with unfavorable-risk prostate cancer,Unfavorable Intermediate-Risk Prostate Cancer and the Odds of Upgrading to Gleason 8 or Higher at Prostatectomy,WE-FG-BRA-02: Docetaxel Eluting Brachytherapy Spacers for Local Chemo-Radiation Therapy in Prostate Cancer,Comorbidity and androgen deprivation therapy use in men undergoing high-dose radiation for unfavorable-risk prostate cancer,Influence of Comorbidity on the Risk of Mortality in Men With Unfavorable-Risk Prostate Cancer Undergoing High-Dose Radiation Therapy Alone,Comorbidity and the Receipt of Curative Therapy for Favorable-risk Prostate Cancer Prior to and Following the Publication of PIVOT,Long-term Follow-up of a Randomized Trial of Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer,Risk Group and Death From Prostate Cancer,Whole Pelvis Versus Prostate-Only Radiotherapy With or Without Short-Course Androgen Deprivation Therapy and Mortality Risk,Age, Comorbidity, and the Risk of Prostate Cancer-Specific Mortality in Men With Biopsy Gleason Score 4+3: Implications on Patient Selection for Multiparametric MRI,Toward Personalizing the Use of Androgen Deprivation Therapy to Maximize Benefit and Minimize Harm,Racial Disparities in Prostate Cancer–Specific Mortality in Men With Low-Risk Prostate Cancer,The impact of PSA and digital rectal examination on the risk of prostate cancer specific mortality in men with a PSA level <2.5 ng/ml,Percent positive biopsy cores and the risk of death from prostate cancer in men with unfavorable-risk prostate cancer,Defining a Standard Set of Patient-centered Outcomes for Men with Localized Prostate Cancer,Adverse Effects of Androgen Deprivation Therapy and Strategies to Mitigate Them,Maximum Tumor Diameter and the Risk of PSA Failure After Radical Prostatectomy,40 poster: Biological In-Situ Dose Painting for IGRT (BIS-IGRT) by Use of Drug-Loaded Implantable Fiducials and Spacers,PSA Velocity at Presentation as a Predictor of Prostate Cancer Aggressiveness,730: Short- Versus Long-Term Androgen Suppression Plus External Beam Radiation Therapy and Survival in Men with High-Risk Adenocarcinoma of the Prostate,523: Prostate-Specific Antigen Velocity and the Odds of Identifying Prostate Cancer at Biopsy,1189: Clinical Risk Group Predicts for PSA Recurrence Following Radical Prostatectomy and Adjuvant Radiotherapy: From the Capsuretm Database,Pretreatment PSA Velocity and Risk of Death From Prostate Cancer Following External Beam Radiation Therapy,Evidence to Support that Serial Screening Decreases Prostate Cancer-Specific Mortality,Evidence to support a decline in prostate cancer-specific mortality,Predictors of prostate cancer-specific mortality following radical prostatectomy or radiation therapy,Using patient-reported outcomes to assess prostate brachytherapy technique,The clinical significance of a PSA nadir > 0.2 to patients with a rising post-operative or post-radiation PSA treated with androgen deprivation,Intermediate end point for survival for patients with hormone refractory metastatic prostate cancer,Determination of mean population values of the prostate-specific antigen test after correcting for verification bias,1678: Identifying Patients at Risk for Benign Versus Life Shortening Postoperative Prostate-Specific Antigen Failure,Androgen Suppression Plus Radiation Therapy for Prostate Cancer—Reply,Is there a role for local therapy alone in treatment of high grade prostate cancer?
Objective Some men with unfavorable intermediate-risk prostate cancer (PC) have occult disease with a Gleason score of 8 or higher unrecognized on biopsy because of a sampling error that would change management to long from short course androgen-deprivation therapy in conjunction with radiotherapy. Methods Anthony V. D'Amico, M.D., Ph.D. Dr. D'Amico is the Professor and Chief of Genitourinary Radiation Oncology and MR Guided Prostate Brachytherapy Programs at Dana-Farber Cancer Institute and Brigham and Women's Hospital. Objective
Urology 2000; 55:752-576.D'Amico AV, Weinstein M, Li X, Richie JP, Fujimoto J. Optical coherence tomography as a method for identifying benign and malignant microscopic structures in the prostate gland. Popular hair-loss drug impedes prostate cancer detection in middle-aged men News |
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